Researchers Report Promising Results in Diabetes Stem-cell Treatment -- But Don't Say 'Breakthrough' Yet

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Keep those fingers crossed


The front line of advanced biomedical research doesn't stand still. Whether it's promising advances or devastating setbacks, this field of human knowledge is so young -- and so populated by bright and ambitious scientists and entrepreneurs -- that it seems news is always breaking.

That was certainly the case this week. On Wednesday, we published a cover story on the dilemma facing San Francisco medical scientists trying to deliver on the unrealistic expectations raised by Proposition 71, the 2004 state ballot initiative that allotted $3 billion to stem-cell research. Many of the researchers we spoke to said embryonic-stem-cell-based therapies for severe diseases such as Parkinson's or Alzheimer's are still distant, and that trying to produce cell treatments prematurely would entail substantial risks to patients.

Also this week, however, Brazilian and U.S. researchers reported what appeared to be a step forward in cell science related to another incurable disease: Diabetes. According to a report in the Journal of the American Medical Association, most of 23 patients who received a transplantation of their own blood stem cells survived for months and in some cases years without insulin injections, which they otherwise needed to survive.

This is a big step -- though not as big, perhaps, as diabetics would like. For one thing, all of the patients in the study eventually need to start taking insulin shots again. There were also some less-than-desirable side effects. The patients needed chemotherapy to suppress their immune systems as part of the therapy. Additionally, some patients in the study developed pneumonia and sperm deficiency. All in all, then, this may not sound like a desirable alternative to insulin shots for some people, and the scientific community was divided over the study's significance.

Just goes to show: In the highly politicized world of stem-cell research, progress is rarely as clearly defined as campaign sloganeers would like.

Photo by kaibara87.
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